The only problem is ho/po, but there's no way around that.
That's exactly the problem that appears due to this.
I do know that in terms of tone height the note is the same due to how a guitar would be tuned, (like an E-tone you could get by holding the fifth fret on the A-string and similar) but that doesn't change the fact that on the guitar, as seen in the example, the note is on a different position altogether. Now this does not appear often but is still there and can be the cause of some charts in FOF having picks within solo's that should not be there, about any version of Handroid I have seen, barring Adohu's, thus far has that while it should be tapping all the way through. That brought it under my attention.
I know my point is kinda vague but I hope it is clear that it is a problem to be aware of while fretting.